Effect of targeted sedation by dexmedetomidine Infusion on Serum Glucose, Hemoglobin and Liver Enzymes in mechanically ventilated Patients With Sepsis in intensive care.

Shehata, Marlyn Zarif; Abo Elhessein, Amany Khairy; Aly, Lamiaa Hamdy; Abdou, Khaled Ahmed; Mohamed, Shadwa Rabea

doi:10.21608/mjmr.2025.360137.1906

Effect of targeted sedation by dexmedetomidine Infusion on Serum Glucose, Hemoglobin and Liver Enzymes in mechanically ventilated Patients With Sepsis in intensive care.

Articles in Press

Document Type : Original Article

Authors

¹ anaesthesiology and ICU department ..minia university

² Anesthesiology and ICU departement. Minia. university. Minia.Egypt

³ Department of clinical pathology, faculty of medicine, minia university ,Minia, Egypt.

⁴ Anesthesiology and ICU, faculty of medicine, Minia university, Minia, Minia

⁵ Anaethesia and ICU department. Faculty of medicine. Minia. egypt

10.21608/mjmr.2025.360137.1906

Abstract

Background:

Infection, trauma, or surgery can set off sepsis, a systemic inflammatory reaction that is both severe and extensive. The hallmark is extensive cell death brought on by the overproduction of inflammatory mediators such tumor necrosis factor and interleukins. Acute liver injury and stress-induced hyperglycemia are both brought about by the subsequent synthesis of stress hormones like adrenaline and corticosteroids. By acting on sympatholytic receptors, the centrally acting and very selective alpha receptor agonist dexmedetomidine reduces inflammation.

Aim: with the goal of learning if sepsis-related stress hyperglycemia, liver damage, serum hemoglobin levels, and the Glasgow Coma Scale may be alleviated with the administration of dexmedetomidine infusion.

Patients and Methods: Forty sepsis patients requiring mechanical ventilation in the intensive care unit at Minia University Hospital participated in this prospective, randomized, single-blinded trial. Two equal groups of patients were formed:

• Group I (Control Group): A loading dosage of midazolam ranging from 0.01-0.05 mg/kg was administered to patients, who were thereafter maintained on a maintenance dose of 0.05-0.2 mg/kg/hour.

• Group II (Dexmedetomidine Group): An initial primary dosage of 1 µg/kg of dexmedetomidine was administered to patients during a 10-minute period, after which they were given a maintenance infusion of 0.2-0.6 µg/kg/hour.

Results: significant reduction in serum glucose levels on fifth day post admission with p-value equal 0.03 with dexmedetomidine infusion. However, there was no significant impact was observed on liver enzyems , Glasgow Coma Scale (GCS) or hemoglobin levels.

Conclusion: Dexmedetomidine infusion effectively lowered serum glucose in septic patients.

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