Clinical Evaluation of Intraoperative Injection Platelet Rich Plasma on Cleft Palate Repair

Fesal, Nada; Hassan, Khaled Mohamed; Abdelhakim, Amr Khairy; Mohamed, Ahmed Mahrous

doi:10.21608/mjmr.2025.350655.1870

Clinical Evaluation of Intraoperative Injection Platelet Rich Plasma on Cleft Palate Repair

Articles in Press

Document Type : Original Article

Authors

¹ Plastic And Reconstructive Surgery, Faculty of Medicine – Minia University.

² Professor of Plastic and Hand surgery, Plastic Surgery Department, Faculty of Medicine, Minia University, Egypt

³ Plastic Surgery Department Faculty of Medicine-Minia University

⁴ Professor & head of Plastic & reconstructive surgery department , minia university

10.21608/mjmr.2025.350655.1870

Abstract

Background:Cleft lip and palate are considered as one of the most common congenital anomalies. One of the challenging problems in wound healing that occur after surgical repair of cleft palate is wound dehiscence and fistula formation.Platelet-rich plasma is a concentrate of autologous platelets and plasma that has recently tried to prevent these complications.

Aim of Study: Evaluate the outcome of the use of autologous platelet-rich plasma in primary repair of cleft palate.

Patients and Methods: Twenty patients were classified into two groups

Group A was the control group.It included ten patients had cleft secondary palate and was operated up on without intraoperative use of plasma-rich plasma

Group B was the study group.It included ten patients had cleft secondary palate and was operated up on with intraoperative injection of plasma-rich plasma

Results: By comparing the baseline and operative data between cases with and without fistula, it was found that,there is non-significant difference regarding age, gender,Post palate shelf gap and side of cleft palate (p value >0.05).

By comparing the post-operative data between studied groups, it was found that, there was significant difference between the studied groups regarding the incidence of wound dehiscence, wound infection,fistula and Regurgitation of fluid from nose (p value <0.05) with better outcome in study group.

Conclusion:concomitant intraoperative injection of PRP during palatal repair was found to be adventigious in reducing the incidence of fistula formation and it requires more time to assess whether further surgery is necessary or if the fistula can be managed with conservative treatment.

Keywords

Main Subjects